In a very recent review, we described the identification as well as characterization of a fresh atypical opioid receptor with unique detrimental regulatory properties in direction of opioid peptides.one Our success showed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a broad-spectrum sca